What is DMG?

Proponents of DMG supplements claim it enhances the immune system, boosts neurological function and athletic performance and helps treat epilepsy and autism, according to the MSKCC. Sahelian calls DMG an anti-stress supplement that may have anti-aging effects, ” Read more here.

Dimethylglycine is a highly unusual supplement, in that it is extremely popular despite the fact that all of its touted effects have largely been refuted by clinical and laboratory testing. It is most widely used as a performance enhancer by athletes, and in dogs and horses that are bred for racing purposes. Specifically, DMG is thought to be able to reduce lactic acid build up that might otherwise contribute to muscle fatigue. There is no immediately obvious reason why DMG should be able to achieve this, given its role in the body as a metabolite of betaine and a source of glycine. Reports of an ability of DMG to enhance athletic performance first appeared in the popular literature in the 1980's. Controlled studies involving treadmill horses, male athletes, and patients prone to lactic acid build up due to a cytochrome oxidase deficiency fail to support these earlier claims. Other common uses of DMG which have been refuted by clinical research include the treatment of autism and idiopathic epilepsy.

'...all of its touted effects have largely been refuted by clinical and laboratory testing.'

DMG is also touted as an immune stimulant, although it has no role in the body that could directly account for this effect. A double blind study in the early 1980's showed increased immune function (both humoral and cell-mediated) in humans following supplementation with DMG. Another study suggested this increased immune response could translate into a protective effect against cancer. A comprehensive study in 1992 failed to demonstrate any immune enhancing properties of DMG in cats.

What is the function of DMG?

DMG is a metabolite of betaine, which is used to help promote the production of methionine from homocysteine. Abnormal homocysteine levels are associated with autism and with coronary artery disease, but DMG does not stimulate reactions that reduce homocysteine, but is a by-product of them. DMG may also eventually be converted into two very vital compounds, phosphatidylserine and glutathione, but a direct effect has not been demonstrated. Indeed, in one study, DMG supplementation actually reduced glutathione levels.

'DMG does appear to function as an antioxidant, and has been shown to have a protective effect against gastric ulceration.'

DMG does appear to function as an antioxidant, and has been shown to have a protective effect against gastric ulceration.

Why recommend the administration of DMG to my pet?

Despite the lack of supportive research, DMG is used to enhance athletic performance in dogs and horses. It may also function as an antioxidant, and be of some benefit in reducing inflammation. DMG may also be recommended for the treatment of immune deficiency disorders, cancer, epilepsy and cognitive disorders, although research support for these uses is lacking.

How much experience is there with the use of DMG in pets?

DMG has been used for over 20 years in humans, racing dogs and horses. While not necessarily clinically effective, DMG is at least extremely well tolerated and very safe, which is not surprising given that it is a metabolite already present in the body. No toxicity has been reported to DMG supplementation. It is important to note that practitioners who use DMG are convinced of its efficacy, and report positive clinical outcomes, despite the lack of research support.

Where do I get DMG and do I need a prescription?

Pet owners are cautioned against buying supplements without knowledge of the manufacturer, as supplements are not highly regulated and some supplements may not contain the labelled amount of ingredients. Your veterinarian may have preferred supplements that he or she will recommend. A prescription is not needed for DMG.

Dmg Supplement For Dogs

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Dmg Supplement Dosage For Autism Treatment

Millions of Americans take dietary supplements for a variety of purposes, including general health, athletic performance and as alternative therapy for an illness. Dimethylglycine, a derivative of the amino acid glycine, is a less commonly known substance available as a supplement. It has antioxidant properties. People take DMG as a supplement for a number of purported benefits; however, clinical data to support most claims are lacking. Talk to your doctor before taking supplements of any kind, including DMG.

Unraveling DMG

DMG is produced as a result of metabolizing choline, an amino acid that plays a role in cell signaling, nerve transmission and fat metabolism. DMG is found naturally in certain foods like beans, cereal grains and liver. It appears that DMG plays a role in producing glutathione during fetal development, according to the Memorial Sloan-Kettering Cancer Center. Glutathione is your body's primary antioxidant.

Dimethylglycine Autism Dosage

DMG Uses

Some people use DMG for antioxidant benefits. Antioxidants neutralize unstable atoms called free radicals, which can cause oxidative damage. This occurs when the body has more free radicals than it can handle at any given time. DMG also increases oxygenation at the cellular level, which may be why some people use it to enhance athletic performance. DMG has been used to boost the immune system, and to treat autism and chronic fatigue syndrome.

Supporting Clinical Data

Very few DMG studies exist and those that do fail to validate claims for most uses. There is no evidence that DMG improves athletic performance or chronic fatigue. Studies to support its use for autism have been mixed. DMG does provide cellular protection against formaldehyde, according to a study published in the 2009 edition of 'The Journal of Biological Chemistry.' Formaldehyde is a toxic substance naturally present in the environment, and it results from certain metabolic processes.

Points to Consider

At the very least, DMG appears to provide antioxidant benefits, but you can get antioxidants from eating a diet rich in fruits and vegetables. A recommended dose has not been established, so follow the manufacturer's instructions. DMG is non-toxic and no adverse side effects have been reported, according to the Memorial Sloan-Kettering Cancer Center. Discontinue use if you experience unwanted effects that you suspect are related to DMG.

About the Author

Janet Renee is a clinical dietitian with a special interest in weight management, sports dietetics, medical nutrition therapy and diet trends. She earned her Master of Science in nutrition from the University of Chicago and has contributed to health and wellness magazines, including Prevention, Self, Shape and Cooking Light.

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